Nahum Sonenberg Selected Research

Peptide Initiation Factors (Initiation Factor)

10/2021	High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors.
1/2021	mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
1/2020	Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
1/2018	Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity.
1/2018	Beyond molecular tumor heterogeneity: protein synthesis takes control.
1/2018	Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.
1/2017	Translational control and the cancer cell response to stress.
12/2015	Translational control of nociception via 4E-binding protein 1.
4/2015	Targeting the translation machinery in cancer.
1/2015	Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.

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Nahum Sonenberg Research Topics

Disease

64	Neoplasms (Cancer) 10/2021 - 11/2002
13	Carcinogenesis 11/2020 - 04/2004
9	Breast Neoplasms (Breast Cancer) 10/2020 - 06/2004
7	Infections 01/2018 - 12/2004
6	Insulin Resistance 01/2017 - 02/2003
5	Starvation 01/2020 - 08/2005
5	Obesity 01/2017 - 02/2007
4	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 04/2007
4	Prostatic Neoplasms (Prostate Cancer) 08/2019 - 03/2007
4	Fragile X Syndrome (Martin Bell Syndrome) 01/2019 - 09/2008
4	Hypoxia (Hypoxemia) 01/2018 - 11/2002
4	Neoplasm Metastasis (Metastasis) 01/2018 - 03/2011
4	Type 2 Diabetes Mellitus (MODY) 12/2017 - 11/2006
4	Pain (Aches) 09/2017 - 07/2013
4	Hypersensitivity (Allergy) 01/2017 - 11/2005
4	Ascites 06/2012 - 01/2004
3	Autistic Disorder (Autism) 01/2021 - 08/2015
3	Autism Spectrum Disorder 01/2021 - 01/2013
3	Melanoma (Melanoma, Malignant) 01/2021 - 05/2012
3	Inflammation (Inflammations) 01/2020 - 07/2002
3	Virus Diseases (Viral Diseases) 04/2012 - 12/2004
2	Tuberous Sclerosis (Bourneville's Disease) 01/2021 - 11/2007
2	Nervous System Diseases (Neurological Disorders) 11/2019 - 01/2019
2	Squamous Cell Carcinoma of Head and Neck 01/2019 - 03/2010
2	Neuralgia (Stump Neuralgia) 01/2019 - 09/2011
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019 - 07/2012
2	Chronic Pain 01/2017 - 12/2015
2	Peripheral Nerve Injuries 01/2017 - 09/2011
2	Hyperalgesia 12/2015 - 09/2011
2	Hyperinsulinism (Hyperinsulinemia) 08/2010 - 11/2006
1	COVID-19 01/2022
1	Retinoblastoma (Glioblastoma, Retinal) 10/2021
1	Lymphoma (Lymphomas) 10/2021
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2021
1	Social Phobia 01/2021
1	Epilepsy (Aura) 01/2021
1	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 01/2021

Drug/Important Bio-Agent (IBA)

42	Proteins (Proteins, Gene)FDA Link 10/2021 - 11/2002
33	Eukaryotic Initiation Factor-4EIBA 10/2021 - 04/2004
21	Peptide Initiation Factors (Initiation Factor)IBA 10/2021 - 11/2002
19	Mechanistic Target of Rapamycin Complex 1IBA 01/2021 - 11/2009
18	Phosphotransferases (Kinase)IBA 01/2021 - 11/2002
16	TOR Serine-Threonine KinasesIBA 10/2021 - 02/2007
10	Messenger RNA (mRNA)IBA 10/2021 - 01/2004
10	Metformin (Glucophage)FDA LinkGeneric 01/2019 - 11/2006
10	Sirolimus (Rapamycin)FDA Link 01/2019 - 07/2008
7	MTOR InhibitorsIBA 01/2021 - 03/2010
7	Eukaryotic Initiation Factor-4F (EIF4F)IBA 12/2018 - 06/2004
6	Pharmaceutical PreparationsIBA 12/2019 - 11/2006
5	Biomarkers (Surrogate Marker)IBA 10/2020 - 12/2012
5	Insulin (Novolin)FDA Link 06/2014 - 02/2003
4	Protein Kinases (Protein Kinase)IBA 08/2013 - 12/2004
3	Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)IBA 01/2020 - 05/2004
3	Antiviral Agents (Antivirals)IBA 01/2018 - 12/2004
3	Carrier Proteins (Binding Protein)IBA 01/2018 - 04/2007
3	Adenosine Monophosphate (AMP)IBA 08/2013 - 09/2011
3	MicroRNAs (MicroRNA)IBA 06/2012 - 09/2007
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021 - 08/2019
2	TensinsIBA 01/2021 - 08/2019
2	tomivosertibIBA 01/2021 - 01/2019
2	Adenosine Triphosphatases (ATPase)IBA 10/2020 - 08/2019
2	CytokinesIBA 01/2020 - 03/2015
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 08/2019 - 01/2019
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2019 - 07/2013
2	InterferonsIBA 12/2018 - 01/2011
2	RNA Cap-Binding Proteins (Cap Binding Protein)IBA 01/2017 - 11/2009
2	Eukaryotic Initiation Factor-2 (EIF 2)IBA 06/2016 - 12/2004
2	DNA (Deoxyribonucleic Acid)IBA 05/2016 - 01/2015
2	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 10/2015 - 11/2005
2	Mitogen-Activated Protein KinasesIBA 10/2015 - 11/2009
2	NexusIBA 01/2015 - 10/2012
2	Antineoplastic Agents (Antineoplastics)IBA 01/2015 - 11/2006
2	Cisplatin (Platino)FDA LinkGeneric 01/2015 - 11/2005
2	Immunosuppressive Agents (Immunosuppressants)IBA 07/2013 - 01/2009
2	Small Interfering RNA (siRNA)IBA 11/2011 - 11/2006
2	AMP-Activated Protein KinasesIBA 09/2011 - 10/2008
2	eIF-4BIBA 10/2010 - 03/2010
2	Growth InhibitorsIBA 10/2008 - 11/2006
2	Blood Glucose (Blood Sugar)IBA 11/2007 - 11/2006
1	mRNA VaccinesIBA 01/2022
1	NucleotidesIBA 10/2021
1	Oncogene Proteins (Oncogene Protein)IBA 10/2021
1	5' Untranslated Regions (5' UTR)IBA 10/2021
1	Untranslated Regions (Untranslated Region)IBA 10/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2021
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021
1	6-hydroxynorketamineIBA 01/2021
1	AntigensIBA 01/2021
1	Kainic Acid (Kainate)IBA 01/2021
1	Antidepressive Agents (Antidepressants)IBA 01/2021
1	Hallucinogens (Psychedelics)IBA 01/2021
1	ParvalbuminsIBA 01/2021
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2021
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2021
1	EnzymesIBA 01/2021
1	Alanine (L-Alanine)FDA Link 01/2021
1	Pentylenetetrazole (Metrazol)IBA 01/2021

Therapy/Procedure

24	Therapeutics 01/2021 - 11/2002
3	Drug Therapy (Chemotherapy) 01/2021 - 01/2018
2	Immunotherapy 01/2021 - 12/2018